Jeremy Baskin is an Assistant Professor in the Department of Chemistry and Chemical Biology and a member of the Weill Institute for Cell and Molecular Biology. A native of Montreal, Canada, Jeremy attended the Massachusetts Institute of Technology, earning a bachelor’s degree in Chemistry, with minors in Biology and Music, in 2004. He carried out his graduate studies in Carolyn Bertozzi’s laboratory in the Department of Chemistry at UC Berkeley, where he harnessed the power of synthetic chemistry to create new tools for imaging the dynamics of biological macromolecules in live cells and organisms. After receiving his Ph.D. in Chemistry in 2009, Jeremy moved to the Department of Cell Biology at the Yale School of Medicine, where he was a postdoctoral fellow in the laboratory of Pietro De Camilli and developed a passion for membrane biology and lipid metabolism. Jeremy joined the faculty at Cornell University in August 2015; his research laboratory will employ a unique blend of chemical biology and cell biology to answer fundamental questions about lipid signaling.
Our research will center on pioneering innovative chemical approaches to probe the cell biology of diverse classes of lipids, with a major focus on developing new molecular imaging methods.
Lipids are a diverse group of metabolites that function as energy stores, components of membranes, and signaling molecules, and dysregulation of lipid metabolism occurs in many diseases. While lipids have been traditionally studied using in vitro or genetic techniques, chemical biology approaches can enable the rapid and precise interrogation of lipid biology within living systems. The Baskin Laboratory will deploy a unique blend of chemical biology, biochemistry, and cell biology approaches to develop innovative methods for imaging and probing various classes of lipids in vivo. Collectively, our studies will elucidate mechanisms of fundamental biological processes and also contribute to the understanding of diseases caused by perturbations in lipid metabolism, with a focus on multiple sclerosis and other diseases of the myelin sheath.
- Bumpus, T. W., & Baskin, J. (2016). A Chemoenzymatic Strategy for Imaging Cellular Phosphatidic Acid Synthesis. Angewandte Chemie: International Edition. 55:13155-13158.
- Baskin, J. M., Wu, X., Christiano, R., Oh, M. S., Schauder, C., Gazzerro, E., Messa, M., Baldassari, S., Assereto, S., Biancheri, R., Zara, F., Minetti, C., Raimondi, A., Simons, M., Walther, T. C., Reinisch, K. M., & De Camilli, P. (2016). The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nature Cell Biology. 18:132-138.
- Nakatsu, F., Baskin, J., Chung, J., Tanner, L. B., Shui, G., Lee, S., Pirruccello, M., Hao, M., Ingolia, N. T., Wenk, M., & De Camilli, P. (2012). PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. Journal of Cell Biology. 199:1003-1016.
- Baskin, J., Dehnert, K. W., Laughlin, S. T., Amacher, S. L., & Bertozzi, C. R. (2010). Visualizing enveloping layer glycans during zebrafish early embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107:10360-10365.
- Laughlin, S. T., Baskin, J., Amacher, S. L., & Bertozzi, C. R. (2008). In vivo imaging of membrane-associated glycans in developing zebrafish. Science. 320:664-667.
- Baskin, J., Prescher, J. A., Laughlin, S. T., Agard, N. J., Chang, P. V., Miller, I. A., Lo, A., Codelli, J. A., & Bertozzi, C. R. (2007). Copper-free click chemistry for dynamic in vivo imaging. Proceedings of the National Academy of Sciences of the United States of America. 104:16793-16797.