We are pleased to welcome to MCBG Professor Dawen Cai! He is a professor of Cell and Developmental Biology, Biophysics at the University of Michigan. He will present “super-resolution profiling of neuron morphology, synapse connectivity, and molecular identity”. This talk will take place on Thursday, April 3rd, in Weill Hall 226. We hope to see you there!

Pizza and refreshements will be provided!

Talk Abstract:

Neural circuits, composed of intercellular connected neurons with distinct properties lay the physical foundation of any brain function. Identifying subtypes and connections of individual neurons in a circuit is the key to understanding how information is processed and propagated in the brain. In order to obtain a detailed wiring diagram between neurons, we developed a series of sample preparation, multiplex labeling, microscopy, and image processing technologies to allow neuronal identity and connectivity features to be directly measured in a densely labeled mouse brain. Compatible with standard surgical, imaging, and computational instrumentations, our comprehensive circuit mapping toolset will also allow high-resolution neural circuit mapping or general molecular spatial profiling in a broad community.