Participants follow along wtih a demonstration at the REAP Seminar presented by Will Comstock (Smolka Lab)

WELCOME

• Rubha Balu: Postdoctoral Associate, Yu Lab
• Claudia Chambliss: Biophysics Graduate Student, Fromme Lab
• Brian Chen: Chemistry & Chemical Biology Graduate Student, Baskin Lab
• Si Chen: ELMI Postdoctoral Associate, Roeder Lab
• Caitlin Feller: Administrative Assistant, Institute Faculty & Grant Support
• Weiguo He: Postdoctoral Associate, Hu Lab
• Sarah Henretta: Biomedical Engineering Graduate Student, Lammerding Lab
• Esha Shakthy: Student Research/Lab Assistant, Lammerding Lab
• Shaozheng Sun: Research Intern, Mao Lab
• Charlie Sun: Computational Biology Graduate Stu
• Yutong Zhu: Computational Biology Graduate Student, Yu Lab
• Maura Zimmermann: Postdoctoral Associate, Roeder Lab

CONGRATULATIONS

• Jumana Badar awarded The Harry & Samuel Mann Outstanding Graduate Student Award
• Trevor Cross transferred from GRA, Doerr Lab to ELMI Postdoctoral Associate, Roeder Lab
• Tobi Dörr promoted to Associate Professor, Microbiology
• Scott Emr received a lifetime achievement award from the American Society for Biochemistry and Molecular Biology (ASBMB)
• Julia Li (Baskin Lab) awarded NSERC Postgraduate Doctoral Scholarship
• Julien Morival (Lammerding Lab) awarded CVG Scholar Award and American Heart Association Postdoctoral Fellowship
• Priscila Navarro (Yu Lab) promoted to Lab Manager

RECENT PUBLICATIONS

Baskin Lab

• Dylan Chiu: Organelle-Selective Membrane Labeling through Phospholipase D-Mediated Transphosphatidylation.
• Weizhi Yu: A Chemoproteomics Approach to Profile Phospholipase D-Derived Phosphatidyl Alcohol Interactions.
• Dylan Chiu: Imaging and Editing the Phospholipidome.

Bretscher Lab

• Abigail Sulpizio: Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
• Robert Gingras: High-resolution secretory timeline from vesicle formation at the Golgi to fusion at the plasma membrane in  cerevisiae.

Fromme Lab

• Carolyn Highland: Methods for Studying Membrane-Proximal GAP Activity on Prenylated Rab GTPase Substrates.
• Saket Bagde: The TRAPP Complexes: Discriminating GTPases in Context.
• Ryan Feathers: Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation.

Han Lab

• Sasidhar Karuparti/Ann Yeung: A toolkit for converting Gal4 into LexA and Flippase transgenes in Drosophila.

Lammerding Lab

• Jan Lammerding: Mechanobiology of the cell nucleus.

Yu Lab

• Yuan Liu/Shagun Gupta/Mauricio Paramo: A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.

RECENT GRANT AWARDS

Han Lab

• USC / NIH NINDS (Dickman) “Generating functional diversity from molecular homogeneity at glutamatergic synapses”

Lammerding Lab

• CVG Seed Grant “Applying Genomics Approaches to Study Nuclear Mechanotransduction”
• Cornell-NUS Global Strategic Collaboration Award “The juice is worth the squeeze: The role of chromatin architecture in confined migration-induced phase separation”

Smolka Lab

• Cornell-HKUST Global Strategic Collaboration Award “CryoEM structures of eukaryotic DNA replication complexes”

Yu Lab

• CCFI Seed Grant (Bogdanove) “Recognition of pathogen-delivered transcription activator-like effectors by the NLR immune receptor Xo1 in rice”

UPCOMING EVENTS

• February 2nd: Molecular Cell Bio Group, 226 Weill Hall (4pm)
  • Bryce Brownfield (Fromme Lab) “Auto-inhibitory interactions of the Arf GEF Sec7, master  regulator of the Golgi complex”
  • Martin Graef (MBG) “Mechanisms and functions of autophagy”
• February 9th: Weill Institute Diversity Council Meeting, 221 Weill Hall (11:30am)
• February 16th: Weill Institute Happy Hour, Weill Hall 3rd Floor Atrium (4pm)

WELCOME

• Gaby Castro: Student Administrative & Communications Assistant
• Qi-Nan Chen: Postdoctoral Associate, Han Lab
• Louise Wang: Student Administrative & Communications Assistant

FAREWELL

• Hui Ji, Han Lab: Stanford University at Palo Alto, Luo Lab

CONGRATULATIONS

• Saket Bagde (Fromme Lab) awarded ASCB Porter Prize for Research Excellence and Spicer Young Investigator Award
• Misha Kazi (Doerr Lab) awarded Nancy M. and Samuel C. Fleming Research Fellowship
• Yugandhar Kumar (Yu Lab) promotion to Research Associate
• Jan Lammerding named ASCB Fellow, granted BMES Grade of Fellow distinction, and awarded ENG Canaan Family Award for Excellence in Academic Advising
• Yingzheng Jason Wang (Smolka Lab) awarded Nancy M. and Samuel C. Fleming Research Fellowship

RECENT PUBLICATIONS

Baskin Lab

• Xiaofu Cao: Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor.
• Brittany White: Lipid Expansion Microscopy.

Fromme Lab

• Arnold Muccini: Structural basis for activation of Arf1 at the Golgi complex.

Hu Lab

• Mariela Nunez Santos: Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis.

Lammerding Lab

• Chieh-Ren Hsia: Confined migration induces heterochromatin formation and alters chromatin accessibility.

Smolka Lab

• Diego Dibitetto: DNA-PKcs promotes fork reversal and chemoresistance.

Yu Lab

• Alden Leung: Functional genomic assays to annotate enhancer-promoter interactions genome-wide.

RECENT GRANT AWARDS

Doerr Lab

• NSF ENG (Hernandez) “EFRI ELiS: Mechanically Adaptive Living Structural Materials”

Lammerding Lab

• MIT / NIH NCI (Kamm) “Characterizing the functional consequences of mechanical stress during tumor cell extravasation using in vitro microfluidic models”

Roeder Lab

• NSF BIO “URoL:EN: Convergence of biology and architecture: how emergent system dynamics generate adaptable, robust, and resilient forms”

UPCOMING EVENTS

• October 6th: Weill Institute Diversity Council Meeting, Weill Hall 421 (12pm)
• October 18th: Weill Institute Science Workshop – Megan Keller The art of story telling in science communication, Weill Hall 224 (4pm)
• October 20th: Weill Institute Happy Hour, Weill Hall 3rd Floor Lounge (4pm)
• October 24th: Weill Institute Career Workshop Alumni Panel, Zoom (4pm)

WELCOME OUR NEW COLLEAGUES

• Rhiannon Clements, Laboratory/Research Technician, Han Lab
• Karly Hooper, Laboratory/Research Technician, Lammerding Lab
• Parker Jarman, Laboratory/Research Technician, Han Lab
• Yifan Shen, CCB Graduate Student, Han Lab
• Jason Wang, Postdoctoral Associate, Smolka Lab

FAREWELL & CONGRATULATIONS

• Sudeep Banjade, Emr Lab: Proteovant Therapeutics (Philadelphia, PA)
• Jeremy Keys, Lammerding Lab: Northwestern University (Evanston, IL)
• Arnold Muccini, Fromme Lab: Biogen (Boston, MA)
• Jung-Ho Shin, Doerr Lab: International Flavors & Fragrances (Philadelphia, PA)
• Abigail Sulpizio, Bretscher Lab: Evozyne (Chicago, IL)
• Reika Tei, Baskin Lab: Stanford University (Stanford, CA)
• Riasat Zaman, Bretscher Lab

RECENT AWARDS & PROMOTIONS

• Jeremy Baskin, promotion to Associate Professor, Chemistry & Chemical Biology
• Tuancheng Feng, promotion to Research Associate, Hu Lab
• Chris Fromme, promotion to Professor, Molecular Biology and Genetics
• Marcus Smolka, appointed Interim Director Weill Institute for Cell and Molecular Biology
• Adrienne Roeder, appointed Interim Associate Director Weill Institute for Cell and Molecular Biology
• Noam Zuela-Sopilniak, promotion to Research Associate, Lammerding Lab

RECENT PAPERS & GRANT AWARDS

Baskin Lab

• Photoaffinity labeling approaches to elucidate lipid-protein interactions.

Emr Lab

• Immunoisolation of Endosomal Recycling Vesicles from Saccharomyces cerevisiae.
• Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase.

Hu Lab

• NIH NIA R21 “Investigating the role of progranulin in TDP-43 proteiopathy”

Lammerding Lab

• Can’t handle the stress? Mechanobiology and disease.
• Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.

Mao Lab

• NIH NIGMS R01 “Di-ubiquitin modification of ubiquitin ligase adaptors in membrane protein downregulation”

Smolka Lab

• A field guide to the proteomics of post-translational modifications in DNA repair.

Yu Lab

• The Simons Foundation SFARI “Cell-type-specific interactome disruption prioritize risk missense mutations for ASD”

UPCOMING EVENTS

• August 5th: Cell Biology Journal Club, Weill Hall 421 (12pm)
• August 9th: Weill Institute Retreat, Greek Peak Mountain Resort – Cortland, NY (8am-5pm)

WELCOME TO OUR NEW COLLEAGUES IN THE WEILL INSTITUTE

• Anna Allen, BMCB Graduate Student, Fromme Lab
• Yuan-Ting Cho, C&CB Graduate Student, Baskin Lab
• Vrushali Fangal, CB Graduate Student, Yu Lab
• Nathan Frederick, C&CB Graduate Student, Baskin Lab
• Michelle Heeney, PB Graduate Student, Roeder Lab
• Yiyang Jin, BMCB Graduate Student, Yu Lab
• Julia Li, C&CB Graduate Student, Baskin Lab
• Cindy Liu, BMCB Graduate Student, Hu Lab
• Yilin Liu, CB Graduate Student, Yu Lab
• Ryan Vignogna, Postdoctoral Associate, Fromme Lab
• Mateusz Wagner, BMCB Graduate Student, Smolka Lab

FAREWELL & CONGRATULATIONS

• Rob Gingras, Bretscher Lab: Manus Bio (Cambridge, MA)
• Ethan Sanford, Smolka Lab: Q2 Solutions (Ithaca, NY)
• Shayne Wierbowski, Yu Lab: Pfizer
• Weizhi Yu, Baskin Lab: WuXi Biologics (Cranbury, NJ)

RECENT AWARDS & PROMOTIONS

• Jumana Badar, awarded Graduate Diversity and Inclusion Community Outreach Award, Smolka Lab
• Sudeep Banjade, promotion to Research Associate, Emr Lab
• Ari Broad, awarded NSF Graduate Research Fellowship, Fromme Lab
• Ryan Feathers, ASBMB Advocacy Training Program delegate, Fromme Lab
• Michelle Heeney, awarded NSF Graduate Research Fellowship, Roeder Lab
• Julia Li, awarded NSERC Postgraduate Doctoral Scholarship, Baskin Lab
• Mariela Nunez Santos, awarded Provost Diversity Fellowship, Hu Lab
• Bryon Rusnak, awarded NSF Graduate Research Fellowship, Roeder Lab
• Sho Suzuki, promotion to Research Associate, Emr Lab
• Reika Tei, awarded Tunis Wentink Prize, Baskin Lab

RECENT PAPERS & GRANT AWARDS

Baskin Lab

• NIH NIGMS R01 “Spatiotemporal control of ubiquitination by phosphoinositide-binding proteins”
• Phosphoinositide phosphorylation sans kinase.

Emr Lab

• Recruitment and organization of ESCRT-0 and ubiquitinated cargo via condensation.

Fromme Lab

• Structure of a TRAPPII-Rab11 activation intermediate reveals GTPase substrate selection mechanisms.

Lammerding Lab

• Assembly and Use of a Microfluidic Device to Study Nuclear Mechanobiology During Confined Migration.

Yu Lab

• NIH NIA R01 “Genome-wide identification and characterization of Alzheimer’s Disease-associated enhancers”

UPCOMING EVENTS

• June 7th: Weill Science Workshop – Will Comstock, Smolka Lab
• June 14th-16th: Keck Biomembrane Retreat
• June 20th: Juneteenth (Staff Holiday)
• July 4th: Independence Day (Staff Holiday)

RECENTLY FUNDED

• Chun Han – NIH NINDS R21 “Mechanisms of natural phosphatidylserine exposure in the nervous system”
• Chun Han – NIH OD R24 “MAGIC tools for genome-wide mosaic analysis with existing Drosophila resources”
• Fenghua Hu – NIH NINDS R01 Renewal “Lysosomal function of progranulin and neurodegeneration”
• Adrienne Roeder – NSF MCB “NSF-ANR: The Biophysical Basis of Flat Organ Morphogenesis From Fluctuating Cellular Growth (GrowFlat)”

WELCOME

• Misha Kazi, Postdoctoral Associate, Doerr Lab
• Katie Munechika, BME Graduate Student, Yu Lab

CONGRATULATIONS

• Carolline Ascencao, awarded ASCB International Training Scholarship, Smolka Lab
• Shagun Gupta, 2022 3MT Competition Finalist, Yu Lab
• Jan Lammerding, inducted 2022 AIMBE Fellow, Lammerding Lab
• Mariela Nunez-Santos, inducted 2022 Cornell Graduate School Bouchet Scholars, Hu Lab
• Masaaki Uematsu, awarded Human Frontiers Science Program fellowship, Baskin Lab
• Masaaki Uematsu, awarded Japan Society for the Promotion of Science Overseas Research Fellowship, Baskin Lab
• Min Wan promoted to Research Associate, Mao Lab
• Xiaochun Wu promoted to higher level Technician, Mao/Hu Labs
• Wenjie Zeng, awarded Sadov Graduate Student Fellowship, Mao Lab

UPCOMING EVENTS

• April 5th, 2pm, Room 224: Weill Institute Science Workshop – Shiying Huang “Introduction to pooled genome-wide CRISPR screening”
• April 28th, 4pm, Room 226: Membrane Signaling Group – TBD

RECENTLY PUBLISHED

Baskin Lab

• Click chemistry and optogenetic approaches to visualize and manipulate phosphatidic acid signaling.
• A palmitoylation code controls PI4KIIIα complex formation and PI(4,5)P2 homeostasis at the plasma membrane.
• Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling.

Bretscher Lab

• The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells †.

Doerr Lab

• High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications.
• Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products.

Han Lab

• Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration.

Hu Lab

• TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
• Differential regulation of progranulin derived granulin peptides.
• Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin.

Roeder Lab

• Cytokinin-CLAVATA cross-talk is an ancient mechanism regulating shoot meristem homeostasis in land plants.
• Stepping on the molecular brake: Slowing down proliferation to allow differentiation.
• Fifteen compelling open questions in plant cell biology.

Smolka Lab

• Phosphoproteomics of ATR signaling in mouse testes.

Yu Lab

• Deep learning methods for 3D structural proteome and interactome modeling.
• Advancing discovery of risk-altering variants for complex diseases by functionally informed fine-mapping.
• A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers.
• Implications of disease-related mutations at protein-protein interfaces.
• A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.